When CO2 gas infused into the skin, immediately diffuses into the cutaneous and muscular microcirculatory levels, resulting in higher tissue oxygenation and neoangiogenesis. Applying carbon dioxide topically creates an acidic environment in the skin. When infused into the skin, CO2 immediately diffuses at the cutaneous and muscular microcirculatory levels. This triggers the body’s response to a decrease in the affinity of hemoglobin for oxygen due to an increase in CO2 and increased oxygen delivery to the treated area, along with vascular endothelial growth factors. After treatment, oxygen distribution and microcirculation in the skin improve. Lymphatic drainage also increases, which aids skin regeneration. The increased oxygenation and improved circulation allow the accumulation of natural growth factors. Skin regeneration occurs through the creation of new blood vessels (angiogenesis) and lymphatic vessels (lymphangiogenesis). Overall, the cascade of effects stimulated by carbon dioxide absorption into the skin aims to regenerate and rejuvenate the skin through enhanced oxygenation, circulation and growth factors.

Future 

Mesenchymal stem cells (MSCs) exosomes have been utilized as an ingredient in cosmetic skincare products and cosmetics due to their anti-inflammatory and therapeutic properties. Growth factors, cytokines, and microRNAs are just a few of the substances found in MSC-derived exosomes that may help with the appearance of aged skin. Exosomes originating from MSCs may aid in the promotion of collagen synthesis, which is necessary to preserve skin suppleness and reduce the visibility of fine lines and wrinkles. Exosomes made from MSCs may also aid in enhancing skin tone and texture, lessening and enhancing general skin health.

Our company has shown that anti-aging products that include MSC-derived exosomes are more successful in encouraging skin renewal and regeneration. For those looking for non-invasive, non-surgical anti-aging therapies, this could be helpful.